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PLEASE NOTE. This Treatment Table was compiled with the assistance of the ITP Support Association’s medical advisors and is intended as a quick reference guide listing the common and less common treatments for ITP. Not all the drugs on this list are necessarily right for every ITP patient – for example some with unpleasant side effects might only be used where a patient has very severe symptoms. It is not intended as a prescription list to take to your consultant and to be worked through from top to bottom! Neither does it include the ‘no treatment’ approach often recommended, particularly for children and adults with mild or unsymptomatic ITP. Being mentioned in the list does not indicate if a treatment is licensed or has NICE approval (in the UK), nor does it indicate the order in which treatments may be used.
Orally – by mouth, Intravenously – into the vein, Subcutaneously – under the skin
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Steroid
| Suppress immune system; decrease platelet destruction | Short-term: Common: irritability, anxiety, insomnia |
Tavlesse
Administered Orally | ‘Fostamatinib reduces | Very common adverse events include: dizziness, |
Doptelet
| Doptelet is used to treat adults | Feeling tired |
Intravenous Immunoglobulin Administered Intravenously | Block platelet destruction | Common: fever, chills, headache Rarely: meningitis-like |
Anti-D
| Block platelet destruction in the spleen | Common: fever, chills, headache, mild haemolysis Rarely: |
Rituximab
| Suppress immune system; decrease platelet destruction | Common: Fever, chills, rash with infusion. Possible |
Splenectomy
| Remove the major site of platelet destruction | Surgical complications in 10%, death in 0.2-1 %, |
Danazol
| Suppress immune system; decrease platelet destruction | In women: male pattern hair growth. In all patients: |
Dapsone
| Unknown | Anaemia; skin rash |
Azathioprine
| Suppress immune system; decrease platelet destruction | Increased risk for infection |
Cyclophosphamide
| Suppress immune system; decrease platelet destruction | Increased risk for infection, urinary bladder |
Vincristine or Vinblastine
| Suppress immune system; decrease platelet destruction | Hair loss, muscle pain, neuropathy (numbness, weakness of |
Mycophenolate
| Suppress immune system; decrease platelet destruction | Nausea, diarrhoea; increased risk for infection |
Plasmapheresis
| Removal of antibodies from blood | None. May need surgical line to be inserted with risk of |
Cyclosporine
| Suppress immune system; decrease platelet destruction | Tremor, impaired kidney function; high blood pressure, |
Nplate (Romiplostin)
| Stimulate platelet production | No important side effects recognized in current clinical |
Eltrombopag
| Stimulate platelet production | Abnormal loss of |
Helicobacter Pylori Treatment
| Eradication may remove a stimulus for ITP | Allergic reactions to the medicines (rare) |
Vitamin C Supplements
| Unknown | Potential increased risk for kidney stones with high |
Platelet Transfusion
| Platelet supplementation (transient response as | Fever, chills (uncommon); transfusion- transmitted |
Tranexamic Acid
| Used to aid clotting | Nausea, diarrhoea, vomiting, disturbance of colour vision |